• Users Online: 307
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2020  |  Volume : 3  |  Issue : 3  |  Page : 437-444

Exploring the prognostic significance of the pretreatment inflammatory markers in hypopharyngeal cancers: A retrospective analysis


1 Department of Surgical Oncology, Cancer Institute (WIA), Chennai, Tamil Nadu, India
2 Department of Medical Oncology, Cancer Institute (WIA), Chennai, Tamil Nadu, India
3 Department of Radiation Oncology, Cancer Institute (WIA), Chennai, Tamil Nadu, India

Correspondence Address:
Arvind Krishnamurthy
Department of Surgical Oncology, Cancer Institute (WIA), 38, Sardar Patel Rd., Adyar, Chennai - 600 036, Tamil Nadu
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/CRST.CRST_152_20

Get Permissions

Background: There is increasing evidence pertaining to the prognostic significance of pretreatment inflammatory markers such as platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and the combination of platelet count and neutrophil-to-lymphocyte ratio (COP-NLR) in many solid tumors, including head and neck cancers. However, there are limited data related to these markers in hypopharyngeal cancers. Objectives: We aimed to explore the association of the pretreatment inflammatory markers with survival outcomes in our cohort of hypopharyngeal cancers. Materials and Methods: The electronic medical records for the consecutive patients with carcinoma of the hypopharynx, treated at our center between January 1, 2016, and December 31, 2016, were accessed. The association between the clinico-demographic-laboratory variables and pretreatment inflammatory markers was analyzed using the Chi-square test, and the survival analysis was performed using the Kaplan–Meier method. Results: Seventy-nine eligible patients were included in the study. The median age of our cohort was 45 years; the male-to-female ratio was 2.9:1. There was a significant association of NLR with sex, hemoglobin, and the primary site; however, no such association was observed between PLR and these variables. Further, our study showed that higher values of NLR, PLR, and COP-NLR were predictive of poor outcomes, both in terms of the disease-free and overall survival. Conclusion: The readily available pretreatment systemic inflammatory markers, such as NLR, PLR, and COP-NLR, can be used as prognostic tools in patients with squamous cell carcinoma of the hypopharynx. The role of these potential markers, especially PLR, appears interesting and warrants further evaluation in other subsites of the head and neck as well.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed210    
    Printed4    
    Emailed0    
    PDF Downloaded108    
    Comments [Add]    

Recommend this journal