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Table of Contents
Year : 2020  |  Volume : 3  |  Issue : 2  |  Page : 372

Author reply to Shamsi et al. and Vora

Department of Medical Oncology, State Cancer Institute, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India

Date of Submission05-Apr-2020
Date of Decision10-Apr-2020
Date of Acceptance12-Apr-2020
Date of Web Publication19-Jun-2020

Correspondence Address:
Avinash Pandey
Department of Medical Oncology, State Cancer Institute, Indira Gandhi Institute of Medical Sciences, Patna, Bihar
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/CRST.CRST_126_20

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How to cite this article:
Pandey A. Author reply to Shamsi et al. and Vora. Cancer Res Stat Treat 2020;3:372

How to cite this URL:
Pandey A. Author reply to Shamsi et al. and Vora. Cancer Res Stat Treat [serial online] 2020 [cited 2021 Dec 9];3:372. Available from: https://www.crstonline.com/text.asp?2020/3/2/372/287203

Shamsi and Usman [1] have pointed out that our use of the term “prevalence” was fallacious in the title of our manuscript, “Prevalence of Vitamin D deficiency in treatment-naive individual consecutive cancer patients.”[2] Prevalence is defined as “The proportion of individuals in a population having a disease or characteristic.”[3] Prevalence is also a statistical concept referring to the number of cases of a disease or deficiency that are present in a particular population at a given time. Our institute is the only regional cancer institute in the Indian state of Bihar. We had previously published our hospital-based cancer registry data and our pediatric data, both as the first and the only publication to date from this part of India.[4],[5] In the absence of a population-based cancer registry, our above data are close to and could be considered the next best representative of the cancer patient profile from this state of India. Hence, our chosen sample of individual consecutive patients used for our Vitamin D study, derived from a similar population, is also a representative of the average cancer patient profile here. Due to this reason, we consider the term “prevalence” apt for our study. Our sample, however, may not be a reflection of patients from the major metropolitan Indian cities.

We concur that comorbidities, complete nutritional status of the patient, body mass index, and biomarkers such as 1,25(OH)D, parathyroid hormone, calcium, magnesium, and phosphate were not reported in our study. These limitations have already been addressed in the discussion section of our published manuscript.[2] Gastrointestinal malignancies, especially esophageal cancer in our study, had a higher prevalence of low Vitamin D level compared to other sites. We believe that this may be due to nutrition limitation arising out of progressive dysphagia. Our study also reiterated that women with breast and ovarian cancer had subclinical Vitamin D deficiency, similar to that seen in normal postmenopausal women in the community.[6] We, however, do not consider the difference in the availability of sunlight to be a major factor for one malignancy compared to others as the cause of selective Vitamin D deficiency in cancer patients.

As highlighted by Vora,[7] our study was an observational, noninterventional cross-sectional study to answer only the question of what the prevalence of Vitamin D deficiency in treatment-naive cancer patients was. We did not pursue the association or causation of cancer due to low Vitamin D levels by comparing with a parallel noncancer age-matched control cohort. We also did not pursue the outcome of patients who took Vitamin D supplementation compared to those who did not, as this was beyond the purview of our study. Whether pretreatment or concurrent Vitamin D supplementation with standard therapy can improve cancer-related outcomes or reduce toxicities needs further exploration.[8]

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There are no conflicts of interest.

  References Top

Shamsi U, Usman S. Causal association of Vitamin D deficiency with cancer: More research needed. Cancer Res Stat Treat 2020;3:369-90.  Back to cited text no. 1
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Pandey A, Singh A, Singh S. Prevalence of Vitamin D deficiency in treatment-naive individual consecutive cancer patients. Cancer Res Stat Treat 2020;3:25-31.  Back to cited text no. 2
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Definition of Prevalence. Available at, https://www.medicinenet.com/script/main/art.asp?articlekey=11697. [Last assessed on 2020 Apr 06].  Back to cited text no. 3
Pandey A, Raj S, Madhawi R, Devi S, Singh RK. Cancer trends in Eastern India: Retrospective hospital-based cancer registry data analysis. South Asian J Cancer 2019;8:215-7.  Back to cited text no. 4
[PUBMED]  [Full text]  
Pandey A, Singh A, Kumar V, Prakash J, Runu R, Thakur V, et al. Pediatric cancers in Bihar: A retrospective tertiary cancer center study. South Asian J Cancer 2020;9:53-5.  Back to cited text no. 5
[PUBMED]  [Full text]  
Harinarayan CV. Prevalence of vitamin D insufficiency in postmenopausal south Indian women. Osteoporos Int 2005;16:397-402.  Back to cited text no. 6
Vora CS. Let us not associate everything with cancer. Cancer Res Stat Treat 2020;3:371.  Back to cited text no. 7
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Batra U, Sharma M. Association of Vitamin D with cancer – Catch me if you can!. Cancer Res Stat Treat 2020;3:78-80.  Back to cited text no. 8
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