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Table of Contents
Year : 2020  |  Volume : 3  |  Issue : 2  |  Page : 371

Let us not associate everything with cancer

Department of Medical Oncology, Byramjee Jeejeebhoy Medical College and Sassoon General Hospital, Pune, Maharashtra, India

Date of Submission10-Mar-2020
Date of Decision12-Mar-2020
Date of Acceptance15-Mar-2020
Date of Web Publication19-Jun-2020

Correspondence Address:
Chakor Sunil Vora
C - 4, Flat No. 13, Maniratna Complex, Aranyeshwar, Pune - 411 009, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/CRST.CRST_80_20

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How to cite this article:
Vora CS. Let us not associate everything with cancer. Cancer Res Stat Treat 2020;3:371

How to cite this URL:
Vora CS. Let us not associate everything with cancer. Cancer Res Stat Treat [serial online] 2020 [cited 2021 Oct 23];3:371. Available from: https://www.crstonline.com/text.asp?2020/3/2/371/287271

The role of Vitamin D in cancer pathogenesis, prevention, screening and detection, and treatment has been under investigation for the past three decades. A multitude of studies, ranging from observational studies to meta-analyses, have been undertaken in this field. However, there is still a lack of definitive evidence for the use of Vitamin D in any of these settings and for a possible association of Vitamin D with cancer.[1] As mentioned in the editorial by Dr. Batra, there is a lack of data on this aspect from the Indian setting.[2] Dr. Pandey's observational study of Vitamin D levels in treatment naïve patients with cancer highlights the prevalence of Vitamin D deficiency and insufficiency in our population.[3] However, it is not known whether Vitamin D supplementation will improve the outcome for patients with cancer. As discussed in the study, as well as the editorial, more studies with longer follow-up are needed to prove the benefits of Vitamin D supplementation in patients with cancer. However, extrapolating the evidence for the benefits of Vitamin D supplementation in the general population, we can certainly recommend our patients a course of Vitamin D for its proven benefits on skeletal health.

There have been attempts to associate Vitamin D and the Vitamin D receptor with almost all diseases known to the human race, including disorders of muscle function, autoimmune disorders, infectious diseases, chronic obstructive pulmonary disease, cardiovascular diseases, diabetes, neuropsychiatric function, and all cancers. However, from its discovery in 1919 to this date, there is weak or no evidence for the association of Vitamin D with any of the above-mentioned aspects of human health.[4]

The study by Dr. Pandey is indeed important because it sensitizes us to look for and correct the Vitamin D deficiency in our patients. However, it has been proven time and again that there is no one master-key that opens all locks. Therefore, it is better to use our limited resources to study more relevant targets and hypotheses.

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There are no conflicts of interest.

  References Top

Goulão B, Stewart F, Ford JA, MacLennan G, Avenell A. Cancer and Vitamin D supplementation: A systematic review and meta-analysis. Am J Clin Nutr 2018;107:652-63.3  Back to cited text no. 1
Batra U, Sharma M. Association of Vitamin D with cancer – Catch me if you can! Cancer Res Stat Treat 2020;3:78-80.  Back to cited text no. 2
Pandey A, Singh A, Singh S. Prevalence of Vitamin D deficiency in treatment-naive individual consecutive cancer patients. Cancer Res Stat Treat 2020;3:25-31.  Back to cited text no. 3
  [Full text]  
Bouillon R. Vitamin D and extraskeletal health. UpToDate; 2020. Available from: from www.uptodate.com/contents/. [Last retrieved on 2020 Mar 10].  Back to cited text no. 4

This article has been cited by
1 Author reply to Shamsi et al. and Vora
Avinash Pandey
Cancer Research, Statistics, and Treatment. 2020; 3(2): 372
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