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Table of Contents
Year : 2018  |  Volume : 1  |  Issue : 2  |  Page : 171-172

Induction chemotherapy in recurrent, unresectable esthesioneuroblastoma

1 Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India
2 Department of Radiology, Tata Memorial Hospital, Mumbai, Maharashtra, India

Date of Web Publication17-May-2019

Correspondence Address:
Vijay M Patil
Department of Medical Oncology, Tata Memorial Hospital, Parel, Mumbai - 400 012, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/CRST.CRST_16_18

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How to cite this article:
Dhumal S, Sable N, Patil VM, Vallathol DH, Prabhash K. Induction chemotherapy in recurrent, unresectable esthesioneuroblastoma. Cancer Res Stat Treat 2018;1:171-2

How to cite this URL:
Dhumal S, Sable N, Patil VM, Vallathol DH, Prabhash K. Induction chemotherapy in recurrent, unresectable esthesioneuroblastoma. Cancer Res Stat Treat [serial online] 2018 [cited 2021 Oct 22];1:171-2. Available from: https://www.crstonline.com/text.asp?2018/1/2/171/258533

Dear Editor,

Esthesioneuroblastoma is a rare diagnosis made in the adolescent or young adult age group.[1],[2],[3],[4] The primary modality of treatment for this malignancy is surgery followed by adjuvant radiotherapy.[1],[2] Neoadjuvant chemotherapy has been tried in locally advanced settings and has had good results in selected case series and reports.[3],[4] We report a case of a young male with recurrent esthesioneuroblastoma who was administered neoadjuvant chemotherapy and then treated with chemoradiation.

A 25-year-old male presented to the Head and Neck Outpatient Department at Tata Memorial Hospital in 2013 with complaints of epistaxis and nasal obstruction for 2 months. He underwent left polypoidal excision outside. The histopathology report revealed an olfactory neuroblastoma-Hyam's Grade 3 (Kadish D). Magnetic resonance imaging (MRI) and positron emission tomography (PET)–computed tomography, which were done postoperatively, showed a recurrent mass in the nasal cavity, nasopharynx, and ethmoidal sinuses which invaded the medial wall of the left orbit [Figure 1]a. In view of high-grade and rapid progression of the tumor, he was planned for neoadjuvant chemotherapy with cisplatin–etoposide regimen followed by surgery. He received three cycles of chemotherapy following which the PET scan and MRI showed complete metabolic and significant morphological responses with no intraorbital extension [Figure 1]b. He was then treated with chemoradiotherapy (in view of excellent response). The patient is currently under observation and on regular follow up.
Figure 1: (a) Before induction chemotherapy. (b) After induction chemotherapy

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The usual definitive approach for the treatment of such cases is surgery rather than chemotherapy or radiotherapy. We are submitting this case in view of its rarity and the different treatment approach used.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

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Conflicts of interest

There are no conflicts of interest.

  References Top

Diaz EM Jr., Johnigan RH 3rd, Pero C, El-Naggar AK, Roberts DB, Barker JL, et al. Olfactory neuroblastoma: The 22-year experience at one comprehensive cancer center. Head Neck 2005;27:138-49.  Back to cited text no. 1
Ward PD, Heth JA, Thompson BG, Marentette LJ. Esthesioneuroblastoma: Results and outcomes of a single institution's experience. Skull Base 2009;19:133-40.  Back to cited text no. 2
Patil VM, Joshi A, Noronha V, Sharma V, Zanwar S, Dhumal S, et al. Neoadjuvant chemotherapy in locally advanced and borderline resectable nonsquamous sinonasal tumors (Esthesioneuroblastoma and sinonasal tumor with neuroendocrine differentiation). Int J Surg Oncol 2016;2016:6923730.  Back to cited text no. 3
Aljumaily RM, Nystrom JS, Wein RO. Neoadjuvant chemotherapy in the setting of locally advanced olfactory neuroblastoma with intracranial extension. Rare Tumors 2011;3:e1.  Back to cited text no. 4


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