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DRUG REVIEW
Year : 2020  |  Volume : 3  |  Issue : 2  |  Page : 264-269

Rivaroxaban: Drug review


1 Department of Medical Oncology, HBCH/MPMMCC, Varanasi, Uttar Pradesh, India
2 Department of Medical Oncology, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, India
3 Department of Surgical Oncology, HBCH/MPMMCC, Varanasi, Uttar Pradesh, India
4 Department of Pharmacy, Amity University, Lucknow, Uttar Pradesh, India
5 Department of Biotechnology, Bangalore University, Bengaluru, Karnataka, India

Correspondence Address:
Abhishek Kumar Singh
Department of Medical Oncology, HBCH/MPMMCC, Varanasi, Uttar Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/CRST.CRST_122_19

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Cancer-associated thrombosis is a challenging problem when treating patients with cancer. It is recurrent and difficult to treat because of the increased risk of bleeding. Low-molecular-weight heparin is the standard of care for treating cancer-associated venous thromboembolism/pulmonary embolism (VTE/PE). Recently, there have been emerging data favoring the use of direct oral anticoagulants (DOACs) for treating cancer-associated VTE/PE. They are well tolerated because of oral administration and favorable side effect profile. Rivaroxaban was the first DOAC to be approved by the US Food and Drug Administration in 2012. In this comprehensive review, we discuss the history, chemistry, mechanism of action, indications, dose modifications, and drug–drug interactions of rivaroxaban. We also discuss briefly the results of various clinical trials related to DOACs.


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