• Users Online: 434
  • Print this page
  • Email this page
Year : 2020  |  Volume : 3  |  Issue : 2  |  Page : 254-263

Leptomeningeal metastasis from extracranial solid tumors

Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India

Correspondence Address:
Dr. Kumar Prabhash
Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/CRST.CRST_38_20

Get Permissions

Background: Leptomeningeal metastasis (LM) is a dreaded complication associated with solid tumors which is increasing due to the advances in cancer-directed therapy. Proper diagnostic and treatment criteria are still not established for the handling of LM. This article aims to help outline a management plan for LM. Methods: A systematic review of the articles on LM and solid tumors was done in PubMed for the past 15 years and eligible articles were eligible articles were considered. The articles related to hematological malignancies and brain tumors were excluded. Results and Discussion: LM usually requires a strong suspicion based on the natural history of the disease and symptoms for diagnosis. Symptomatology, cerebrospinal fluid (CSF) examination, and magnetic resonance imaging aid in the diagnosis. The treatment involves a multimodal institution of intra-CSF therapy, systemic chemotherapy, craniospinal irradiation, and surgical interventions for relief of symptoms. The prognosis is usually poor despite treatment and expected survival is between 4 and 6 months. Conclusion: The different options for the treatment of LM should be discussed in a multidisciplinary clinic. The treatment must be decided based on the neurological and general health condition of the patient, previous lines of treatment, and the presence of other metastatic sites. The improvement of levels of evidence for the various therapeutic procedures for patients with LM requires dedicated trials.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded42    
    Comments [Add]    

Recommend this journal