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Table of Contents
LETTER TO EDITOR
Year : 2020  |  Volume : 3  |  Issue : 1  |  Page : 128

Authors' reply to Agarwal and Gupta


Department of Radiation Oncology, Kathmandu Cancer Centre, Mahamanjushree Nagarkot, Nepal

Date of Submission14-Jan-2020
Date of Acceptance14-Jan-2020
Date of Web Publication24-Feb-2020

Correspondence Address:
Sampada Dessai
Department of Surgical Oncology, Sir H. N. Reliance Foundation Hospital and Research Centre, Mumbai, Maharashtra
Nepal
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/CRST.CRST_24_20

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How to cite this article:
Sapkota S, Dessai S. Authors' reply to Agarwal and Gupta. Cancer Res Stat Treat 2020;3:128

How to cite this URL:
Sapkota S, Dessai S. Authors' reply to Agarwal and Gupta. Cancer Res Stat Treat [serial online] 2020 [cited 2020 Mar 30];3:128. Available from: http://www.crstonline.com/text.asp?2020/3/1/128/279102



We thank Agarwal[1] and Gupta[2] for taking a keen interest in our article[3] and the accompanying editorial.[4] We, in general, disagree with the comments made in the editorial and by Dr. Agarwal on the survey response rate. The response rate has typically been used as a tool to evaluate the quality of surveys, and a 60% response rate or above is considered an adequate response.[5] However, this value is based on a rule of thumb assumption and lacks statistical validity. Further procedure for the calculation of response rate is ill-defined and hence frequently investigators calculate it by methods which lead to unrealistic but so-called optimal response rate. To overcome this and maintain high standards of survey-based studies, the American Association for Public Opinion Research has provided specific guidelines for the calculation of response rate.[6] These were followed in the current survey.

The next criticism raised is about the respondents being largely medical oncologists. We are surprised at this comment. Ovarian cancer management is predominantly done by surgical and medical oncologists. In the survey, 33 respondents were from the surgical fraternity, which is 44%, whereas medical oncology contributed to 41.3% of the survey population. Hence, the survey truly depicts a combined opinion of both fraternities.

Testing for BRCA mutation is not only therapeutic but also has implications on the management of the rest of the family members.[7],[8] Counseling and screening needs to provide for the other members. Hence, we disagree with Dr. Agarwal's comment that testing should not be performed if the patient cannot afford the poly ADP ribose polymerase inhibitors.

Finally, we agree that we need India-specific guidelines. However, this suggestion keeps being made in every discussion, but there is no specific action taken. The only way we are going to get India-specific guidelines by doing India-specific research and which the need of the hour is.[9]

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Agarwal P. Treatment pattern of ovarian cancer in Southeast Asia. Cancer Res Stat Treat 2020;3:125-6.  Back to cited text no. 1
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2.
Gupta T. Management of ovarian cancer. Cancer Res Stat Treat 2020;3:126-7.  Back to cited text no. 2
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3.
Sapkota S, Abhyankar A, Dessai S. Ovarian cancer practice survey from the South Asian Association for Regional Cooperation (SAARC) Nations. Cancer Res Stat Treat 2019;2:158-62.  Back to cited text no. 3
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4.
Kaur S, Singh R. Patterns of care for ovarian cancer. Cancer Res Stat Treat 2019;2:217-20.  Back to cited text no. 4
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5.
Johnson TP, Wislar JS. Response rates and nonresponse errors in surveys. JAMA 2012;307:1805-6.  Back to cited text no. 5
    
6.
Standard Definitions – AAPOR. Available from: https://www.aapor.org/Education-Resources/For-Researchers/Poll-Survey-FAQ/Response-Rates-An-Overview.aspx. [Last accessed on 2020 Jan 14].  Back to cited text no. 6
    
7.
Chheda P, Pande S, Dama T, Vinarkar S, Chanekar M, Limaye S, et al. Spectrum of germline BRCA1/2 mutations in hereditary breast and ovarian cancer syndrome in Indian population: A central reference laboratory experience. Cancer Res Stat Treat 2020;3:32-41.  Back to cited text no. 7
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8.
Hussain SM. Molecular-based screening and therapeutics of breast and ovarian cancer in low- and middle-income countries. Cancer Res Stat Treat 2020;3:81-4.  Back to cited text no. 8
    
9.
Noronha V. Making a case for cancer research in India. Cancer Res Stat Treat 2018;1:71-4.  Back to cited text no. 9
  [Full text]  




 

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