|LETTER TO EDITOR
|Year : 2020 | Volume
| Issue : 1 | Page : 122-123
Limb salvage surgery in osteosarcoma: Comment on Indian perspective
Department of Surgical Oncology, Tata Memorial Hospital, Parel; Homi Bhabha National Institute (HBNI), Mumbai, Maharashtra, India
|Date of Submission||13-Jan-2020|
|Date of Acceptance||13-Jan-2020|
|Date of Web Publication||24-Feb-2020|
Department of Surgical Oncology, Tata Memorial Hospital, Dr. E Borges Road, Parel, Mumbai - 400 012, Maharashtra
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Muthusamy S. Limb salvage surgery in osteosarcoma: Comment on Indian perspective. Cancer Res Stat Treat 2020;3:122-3
I have read the original article entitled, 'Life and limb after limb salvage surgery for osteosarcoma in an Indian Tertiary Cancer Center' along with the accompanying editorial, published in the current issue of the journal., I want to congratulate the authors for this article and make some contributions.
The positive thing worth mentioning about this article is that it is a single-institutional study, thereby eliminating the biases due to different surgical techniques and treatment protocols which are inherent to multi-institutional studies and this study has a longer period of median follow-up compared to other studies done in the Indian setting.,,
Apart from reiterating the fact that chemotherapy-induced tumor necrosis is a favorable prognostic factor, the authors have concluded that the oncological outcomes are comparable to other studies from the world literature. I feel that only one of the quoted studies, i.e., by Puri et al., is comparable with the present study, the reason being that three of the studies have smaller sample sizes and shorter period of median follow-up.,, The other two studies by Bielack et al. and Bacci et al. have large sample sizes and long follow-up, but they were done in patients before 1998 and 1989 respectively, and there have been tremendous improvements in surgical techniques, prosthesis, and chemotherapy regimens since then.
The study by Puri et al., is comparable, as it is done in the Indian population around the same time period as the present study, but it has a larger sample size of 853 as compared to 41 in the present study. However, the reported overall survival and event-free survivals were poorer as compared to the Western data and the authors claimed that it was due to delay in referral and large primary tumors in the Indian setting. We would like Dr. Ankalkoti et al. to discuss this furthur.
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Conflicts of interest
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