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Table of Contents
LETTER TO EDITOR
Year : 2019  |  Volume : 2  |  Issue : 2  |  Page : 255-256

Author reply to: Thiagarajan S


Department of Oral and Maxillofacial Surgery, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India

Date of Web Publication20-Dec-2019

Correspondence Address:
Mohammad Akheel
Department of Oral and Maxillofacial Surgery, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/CRST.CRST_71_19

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How to cite this article:
Akheel M, George RK. Author reply to: Thiagarajan S. Cancer Res Stat Treat 2019;2:255-6

How to cite this URL:
Akheel M, George RK. Author reply to: Thiagarajan S. Cancer Res Stat Treat [serial online] 2019 [cited 2020 Sep 23];2:255-6. Available from: http://www.crstonline.com/text.asp?2019/2/2/255/273686



In his letter, Dr. Thiagarajan has questioned the use of depth of infiltration (DOI) as a prognosticator in head-and-neck cancer.[1] There were six systematic review articles included in the present meta-analysis from PubMed search. In the discussion of our article,[2] the difference between DOI and tumor thickness is clearly mentioned as said by Moore et al.[3] In the studies we included, the mean cutoff DOI of oral cavity tumors, irrespective of the subsite of origin in the oral cavity to perform elective neck dissection (END) in pT1/T2 cN0, was in between 2.1 mm and 4.59 mm.[4],[5] We did a statistical analysis of all systematic review analysis and found cutoff DOI to be 4.5 mm, which is in accordance with other studies mentioned in the literature. We did not mention any specific subsite in the oral cavity. We plan to perform a study to find the cutoff DOI for END of every subsite of oral cavity in our patients.

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Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Thiagarajan S. Depth of infiltration cut-off and the need to do an elective neck dissection in early oral cancer- Do we have the final verdict? Cancer Res Stat Treat 2019;2:254-5.  Back to cited text no. 1
  [Full text]  
2.
Akheel M, George RK, Jain A, Chahwala Q, Wadhwania A. Depth of tumor infiltration as a prognosticator in pT1-2 cN0 oral squamous cell carcinoma thereby need for elective neck dissection – A meta-analysis. Cancer Res Stat Treat 2019;2:61-5.  Back to cited text no. 2
  [Full text]  
3.
Moore C, Kuhns JG, Greenberg RA. Thickness as prognostic aid in upper aerodigestive tract cancer. Arch Surg 1986;121:1410-4.  Back to cited text no. 3
    
4.
Melchers LJ, Schuuring E, van Dijk BA, de Bock GH, Witjes MJ, van der Laan BF, et al. Tumour infiltration depth ≥4 mm is an indication for an elective neck dissection in pT1cN0 oral squamous cell carcinoma. Oral Oncol 2012;48:337-42.  Back to cited text no. 4
    
5.
Tarsitano A, Del Corso G, Tardio ML, Marchetti C. Tumor infiltration depth as predictor of nodal metastasis in early tongue squamous cell carcinoma. J Oral Maxillofac Surg 2016;74:523-7.  Back to cited text no. 5
    




 

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