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Year : 2019  |  Volume : 2  |  Issue : 1  |  Page : 105-107

Delirium and seizures in a patient with head-and-neck squamous cell carcinoma on docetaxel, cisplatin, and 5-fluorouracil


Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India

Correspondence Address:
Kumar Prabhash
Department of Medical Oncology, Tata Memorial Hospital, Parel, Mumbai - 400 012, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/CRST.CRST_35_19

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A 33 year male, case of locally advanced carcinoma left buccal mucosa treated with docetaxel, cisplatin and 5-fluorouracil as neoadjuvant therapy developed acute onset delirium, seizures and agitation on fifth day of first cycle of chemotherapy. Although CT brain revealed no abnormality, MRI brain showed symmetric areas of diffusion restriction with T2/FLAIR hyperintensity involving periventricular region (lateral ventricles), centrum semiovale and corpus callosum. His clinical symptoms normalized after one week of stopping therapy. What is the diagnosis, and how should the patient be managed?


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